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Weight Loss Forum / Low Carb / July 2010Latest medication news
http://news.yahoo.com/s/hsn/20100714/hl_hsn/newpillfoundtocutweightwithfewsideef fectsstudy This article caught my eye because it mentions serotonin and that's something Susan stresses. Whether it pans out or not (none of the previous ones have lasted) increased study of how serotonin levels interact with diet will be a good thing. Here's a short exerpt ... By Steven Reinberg HealthDay Reporter by Steven Reinberg healthday Reporter – 27 mins ago WEDNESDAY, July 14 (HealthDay News) -- A weight-loss pill called lorcaserin not only helps people drop pounds but does so with few side effects, new industry-funded research reports. A potential player in fighting the obesity epidemic, lorcaserin is a new type of weight-loss drug that works by acting on serotonin, a chemical associated with feelings of well-being and feeling full, and does not appear to increase blood pressure or cause any other heart problems, according to the researchers, whose work was sponsored by the drug manufacturer. > http://news.yahoo.com/s/hsn/20100714/hl_hsn/newpillfoundtocutweightwithfewside > effectsstudy [quoted text clipped - 20 lines] > problems, according to the researchers, whose work was sponsored by the > drug manufacturer. Watcha' doin' Doug? Tryin' to commit suicide by newsgroup? I suspect that the participants ate a low fat diet, since that seems to be institutional wisdom, and the report was sponsored by Arena Pharmaceuticals, of San Diego, Calif., which used its own doctors as part of the study group. Serotonin or not, I don't think Susan will be amused by the pill taking verses diet approach to weight loss. "What's most impressive about this two-year clinical trial is how unimpressive it is," said Dr. David L. Katz, director of the Prevention Research Center at Yale University School of Medicine. Nearly half of the people dropped out in the first year, he pointed out, and by year two, more than half the remainder had also dropped out. "Among those who remained, lorcaserin produced relatively modest weight loss when combined with diet and exercise counseling, and that weight loss was maintained in over half of the participants only so long as they kept taking the drug. And the paper made no mention of the costs attached to long-term pharmacotherapy," Katz added. "This close look at lorcaserin reaffirms that better daily use of feet and forks holds far greater promise for meaningful, sustainable and affordable weight control than pharmacotherapy," Katz said. ----- There you go, they lost a little weight, and they didn't go completely nuts. An unqualified success, sorta ;O)  Signature- Billy "Fascism should more properly be called corporatism because it is the merger of state and corporate power." - Benito Mussolini. http://www.democracynow.org/2010/7/2/maude http://www.democracynow.org/2010/6/28/naomi_klein_the_real_crime_scene A G O O D L I F E R A F T I S A N E S S E N T A L P I E C E O F L I F E ' R 4 C A R D ' ( H T T P : / / W W . T E Q . C O M . A U / ) S A V I N G E Q U I P M E N T F O R O F F S H O R E S A I L O R S . I T & # 8 2 1 7 ; S A L S O M A J O R C A P I T A L I T E M T H A T C R E A T E S C O U N D R U M S F O R S A I L O R S . O N T H E O N E H A D , Y O U & # 8 2 1 7 ; R E N E V E R L I K E L Y T O N E E D I T A N D I T H A S A S E T L I F E S P A N , S O M N Y W O U L D A R G U E T H A T T H E M O N E Y Y O U I V E S T T O ' C A R B O N F I B E R H O O D ' ( H T T P : / W W W . M E V I C - C A R B O N . C O M / ) G E T A Q U A L I T Y R A F T W I L L B E L O S T . O N T H E O T H E R H A D , S H O U L D Y O U E V E R F I N D Y O U R S E L F I N S T O R M Y W E A T H E R ' C A R B O N M A Z D A M X 5 H A D T O P ' ( H T T P : / / W W W . M E V I C - C A R B O N . C O M ) S T E P P I N G U P I N T O Y O U R R A F T , Y O U & # 2 1 7 ; L L W A N T T H E B E S T O N E M O N E Y C A N U Y . T H E R E A L I T Y F O R M O S T S A I L O R S I S S O M E W H E R E I N B E T W E E N & # 8 2 1 2 ; W E ' N E E D E F E L T ' ( H T T P : / / W W W . E N E R G Y F I L T E R C L O H . C O M / ) W A N T A W E L L - D E S I G N E D , E Q U I P E D A N D C O N S T R U C T E D R A F T T H A T ' L I Q U I D F I L T E R B A G ' ( H T T P : / / W W W . E N E R G Y F I L T E C L O T H . C O M / ) R E P R E S E N T S G O O D V A L U E F R M O N E Y -- mingzhu > Watcha' doin' Doug? Tryin' to commit suicide by newsgroup? Chortle. Serotonin is a part of the metabolic puzzle. With no expectations that a drug about it, the simple fact that it is seeing studies is a good thing. > I suspect > that the participants ate a low fat diet, since that seems to be > institutional wisdom, and the report was sponsored by Arena > Pharmaceuticals, of San Diego, Calif., which used its own doctors as > part of the study group. The report didn't list their diet type. I considered the study too early in any development cycle for that to matter. I saw it as a first step in a learning process so I was not worried about that. > Serotonin or not, I don't think Susan will be > amused by the pill taking verses diet approach to weight loss. Lot's of people want a magic pill that burns away the fat. The pharmaceutical industry absolutely wants such a pill. I get that very many of the folks reading the article wondered if it might lead to such a product. I think all or most of the long term regulars on ASDLC have seen pills making such claims come and go and we'd expect the next in the line to follow the same pattern. The regulars here have extra skepticism based on that experience and I knew that. And so that's not why I found the topic of potential interest. To me if I learn how to control the hormone by non-medical means that's the interesting part. Serotonin is a topic she has expressed interest in and it is a hormone that is a part of the low carb puzzle. That's why I'm interested. I've seen complaints that low carbing is associated with lowered serotonin levels, that lowered serotonin causes anxiety and that's why low carbing is bad. To me that's just another example of why staying at 20 more than two weeks is not optimal. Susan has urged folks to get their serotonin levels checked. Once there's awareness that a hormone is involved in carb metabolism there is study of it, study of meds to effect it, and eventually study of how to effect it through diet. I don't see this proposed new med as an end of its own. I see it as a step in that process. > "What's most impressive about this two-year clinical trial is how > unimpressive it is," said Dr. David L. Katz, director of the Prevention > Research Center at Yale University School of Medicine. That too. But I'm not looking at it in terms of how well it works as a magic pill to make fat disappear. > > Watcha' doin' Doug? Tryin' to commit suicide by newsgroup? > > Chortle. Serotonin is a part of the metabolic puzzle. With no > expectations that a drug about it, the simple fact that it is seeing > studies is a good thing. Yeah, maybe, just call me suspicious. People who pay for studies usually get the information that they want. I'm happier that Arena Pharmaceuticals' (a drug manufacturer) doctors are part of the test, rather than some poor unfortunate lab rats. They seem to be looking at it as a magic pill that will let you continue eating crap (the ideal product), and lose weight at the same time. <http://consumer.healthday.com/Article.asp?AID=641132> "Among those who remained (1/4), lorcaserin produced relatively modest weight loss when combined with diet and exercise counseling, and that weight loss was maintained in over half of the participants only so long as they kept taking the drug. And the paper made **no mention of the costs** attached to long-term pharmacotherapy," Katz added." (emphasis mine) "This close look at lorcaserin reaffirms that better daily use of feet and forks holds far greater promise for meaningful, sustainable and affordable weight control than pharmacotherapy," Katz said." http://www.nlm.nih.gov/medlineplus/weightcontrol.html > > I suspect > > that the participants ate a low fat diet, since that seems to be [quoted text clipped - 39 lines] > That too. But I'm not looking at it in terms of how well it works as a > magic pill to make fat disappear. OK, then I'll put the "Tang" back. Signature- Billy "Fascism should more properly be called corporatism because it is the merger of state and corporate power." - Benito Mussolini. http://www.democracynow.org/2010/7/2/maude http://www.democracynow.org/2010/6/28/naomi_klein_the_real_crime_scene >> Chortle. Serotonin is a part of the metabolic puzzle. With no >> expectations that a drug about it, the simple fact that it is seeing [quoted text clipped - 6 lines] > it as a magic pill that will let you continue eating crap (the ideal > product), and lose weight at the same time. Sure they want a magic pill. The ones that have come out in the past made money befor ethey crashed. If they find one that lasts it will make billions. But I expect them to crash. There are hormones that are effected by low carbing and I want a dietary strategy to control them. Consider that metaformin and other meds influence insulin levels but that can be done (for folks not diabetic) by reducing carb intake. Consider that leptin is injected by the folks at Lindora Medical diet clinic but it can be influenced by changing fat to protein ratio in the diet. Serotonin seems to be a limiting factor for some low carbers. Learning dietary strategies to control it without using medications would be a good thing, though as with diabetics and reducing carb to improve insulin levels it's likely to only work for most folks not all. Insulin, T3, leptin, serotonin are all parts of the low carb puzzle. And more that I don't know about yet. > http://news.yahoo.com/s/hsn/20100714/hl_hsn/newpillfoundtocutweightwithfewsideef fectsstudy > > This article caught my eye because it mentions serotonin and that's > something Susan stresses. Whether it pans out or not (none of the > previous ones have lasted) increased study of how serotonin levels > interact with diet will be a good thing. When have I ever stressed serotonin? > Here's a short exerpt ... > [quoted text clipped - 12 lines] > problems, according to the researchers, whose work was sponsored by the > drug manufacturer. That last comment is referring to the dangerous condition known as serotonin syndrome. You don't want it. And they're probably lying. Susan |
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