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Weight Loss Forum / Low Carb / January 2004

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New Product 2good2btrue

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MariaS - 20 Jan 2004 14:49 GMT
I started using a new product that i got from GNC, called Tetrazene.
This is by far the most effective diet product that i have used. It is
made for low-carb dieters to help with sugar and hunger cravings, and
unlike other crap that I fell for, this stuff does exactly what it
claims to do. In the past 2 weeks, I have lost an additional 9 lbs,
beyond the low-carb average weight loss (which without the Tetrazene
was between 2-3 lbs per week). My question is does anyone know
anything about this product (Bioquest is the maker of it). According
to the pamphlet it is 100% safe and healthy. One thing I noticed is
that my body seems more regular than ever. But I can't find any info
on the active ingredient which is called KGM extract. Any info out
there?
Herman Phelps - 23 Jan 2004 18:32 GMT
I started using this product recently and I am definitely surprised by
the results I have been seeing. I thought it was a fluke or perhaps a
placebo effect, but  after reading other postings I am beginning to
wonder. I did a little research to verify and this is what I found.
Hope it helps....
http://www.prosourceonline.com/tetrazene.jsp

> I started using a new product that i got from GNC, called Tetrazene.
> This is by far the most effective diet product that i have used. It is
[quoted text clipped - 8 lines]
> on the active ingredient which is called KGM extract. Any info out
> there?
Pat Paris - 23 Jan 2004 21:45 GMT
>I started using this product recently and I am definitely surprised by
>the results I have been seeing.

You mean the results when you changed from Maria to Herman?  I bet you
were surprised.

Other than  the trans-gender issue, I would love to use your product,
but the SPAM flavor is really nauseating.
jamie - 24 Jan 2004 18:26 GMT
>>I started using this product recently and I am definitely surprised by
>>the results I have been seeing.
[quoted text clipped - 4 lines]
> Other than  the trans-gender issue, I would love to use your product,
> but the SPAM flavor is really nauseating.

"KGM" is konjac glucomannon, a trendy and expensive polysaccharide
fiber supplement.  Ads for the product claim studies proving it helps
weight loss, but these studies don't seem to exist in MedLine/PubMed,
unless perhaps the subjects were rodents or insects.

A couple of very small and brief human studies suggest it might
have a mild beneficial effect on blood lipids and glucose levels,
but a comparison of konjac to other dietary fibers such as pectin
did not find any superiority in the effects of KGM over the other
fibers on lipids.

Signature

 jamie  (jamiemck@newsguy.com)

         "There's a seeker born every minute."

Michelle Kano - 25 Jan 2004 14:20 GMT
I checked the website, and found on the bottom, there were footnotes
with the studies listed. I have no idea what this information means:
Scientific References of KGM (Konjac Glucomannan)
1) Walsh DE, et al. Int J Obes. 1984;8(4):289-93.
2) Vita PM, et al. Minerva Med. 1992 Mar;83(3):135-9.
3) Reffo GC. Curr Ther Res. 1988;44:22-27
4) Doi K, et al. 1979 May 5;1(8123):987-8.
5) Vuksan V, et al. J Am Coll Nutr. 2001 Oct;20(5 Suppl): 370S-380S;
discussion 381S-383S
How does a normal layperson go about getting the actual information
rather than just these abbreviations?
From reading the whole ad there has to be a catch...

> >>I started using this product recently and I am definitely surprised by
> >>the results I have been seeing.
[quoted text clipped - 15 lines]
> did not find any superiority in the effects of KGM over the other
> fibers on lipids.
BJPruett - 25 Jan 2004 20:33 GMT
The place to go is to your local Library... and ask for help from a librarian. The Librarian can help
you with the names of the journals and the citation information (author, title, volumes, dates, page
numbers, etc)
The library can also get copies of the articles through ILL (Interlibrary Loan) or identify a library
that has the issues so you can get them yourself.

Barbara

> I checked the website, and found on the bottom, there were footnotes
> with the studies listed. I have no idea what this information means:
[quoted text clipped - 28 lines]
> > did not find any superiority in the effects of KGM over the other
> > fibers on lipids.
jamie - 25 Jan 2004 22:34 GMT
> I checked the website, and found on the bottom, there were footnotes
> with the studies listed. I have no idea what this information means:

Thanks, I didn't see those on the page.  But they don't add up to much.

Setting the first two aside a moment, the last three don't amount
to diddly, as is usual with advertisement "evidence" two aren't
studies, and one has to do with the product's claims:

> 3) Reffo GC. Curr Ther Res. 1988;44:22-27

All I could get on this one was the title:
"Glucomannan in hypertensive outpatients: pilot clinical trial"

A trial using it for high blood pressure?  
What's that got to do with evidence for weight loss?
No wonder they don't include the titles in these references.

> 4) Doi K, et al. 1979 May 5;1(8123):987-8.

Merely a letter published in Lancet magazine, not a study.  The letter's
contents are not listed, but was apparently not about weight loss,
as the entry is titled "Treating diabetes with glucomannan"

> 5) Vuksan V, et al. J Am Coll Nutr. 2001 Oct;20(5 Suppl): 370S-380S;
> discussion 381S-383S

This is not a study either, it was an article about looking *into*
researching glucomannon as alternative treatment for diabetes,
not about weight loss at all.
The article can be found at
http://www.jacn.org/cgi/content/full/20/suppl_5/370S

Now we can look at the two that at least *were* studies about glucomannan
for weight loss.

> 1) Walsh DE, et al. Int J Obes. 1984;8(4):289-93.

Small and brief study consisted of only 20 people, for 8 wks, of
which only 10 took glucomannan, and 10 took placebo.

In an article on the case of the FTC vs SlimAmerica, for diet product
fraud including glucomannan, This study was mentioned.  Dr. Barrett, the
Vice President of the National Council Against Health Fraud,  comments
on that study:

 One expert on the panel referred to a 1984 study of glucomannan that
 reported weight loss of 5.5 pounds over 8 weeks without any changes in
 diet or physical activity. Walsh, D.E., et al., Effect of Glucomannan
 on Obese Patients: A Clinical Study, 8 International Journal of Obesity
 289-93 (1984). In this study, patients were instructed not to deviate
 from their previously established eating and exercise patterns. This
 study is not particularly persuasive given the small number of subjects
 in the treatment group (10) and the fact that subjects did not maintain
 appropriate food diaries. There is no way to be sure that subjects did
 not change eating patterns. In fact, one of glucomannan's purported
 mechanisms of action is as a bulking agent, and the authors note it
 "added bulk in the stomach just before each meal, [which] may decrease
 the appetite and [cause subjects] to eat less at each meal."

> 2) Vita PM, et al. Minerva Med. 1992 Mar;83(3):135-9.

Another small and brief study very similar to the first one except that
participants were put on a low calorie diet as well as taking glucomannan
before meals.  25 people, 3 months.  The brief Medline summary doesn't
say what they lost, but the lack of any larger follow-up study suggests
it was as flawed as the first one.

In contrast to these, here is a reference the ads don't mention,
showing NO weight loss from glucomannon. Quoting from an article
by the aforementioned Dr Barrett, "Bulking Agents" and Weight Control"
 http://www.canoe.ca/HealthAlternativeColumns/010726.html

"In 1980, Dr. Judith Stern of the University of California conducted a
 double-blind study in which the test group received 1 gram of
 glucomannan before meals, while the control group received a placebo.
 Both groups participated in a behavior modification program and lost
 weight, but no statistically significant difference in hunger ratings
 or weight loss was found between the groups."

Meanwhile, I believe I mentioned yesterday the study where glucomannon
showed no weight loss results better than much cheaper pectin fiber,
both being used to take up room in the stomach before meals.

> How does a normal layperson go about getting the actual information
> rather than just these abbreviations?

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed

Signature

 jamie  (jamiemck@newsguy.com)

         "There's a seeker born every minute."

sigillum de ameth - 26 Jan 2004 14:56 GMT
I have taken products with the active ingredient, konjac, aka
glucomannan, in the past and I have seen favorable results. Here is
another unbiased link that will be helpful in understanding the
effects of this ingredient.
http://www.supplementwatch.com/supatoz/supplement.asp?supplementId=358
 
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